The increasing prevalence of Crohn’s disease in industrialized societies: The...
With this in mind, IL-10 trials in CD failed to lead to overwhelming effects, suggesting a degree of redundancy in the Th1 maturation process. Furthermore, while IL-10 is upregulated by a Th2-mediated...
View ArticleThe increasing prevalence of Crohn’s disease in industrialized societies:...
It has been well-established that there is crossregulation of the Th1/Th2 immune responses. Cytokines produced by either subset have two characteristic effects on immunodevelopment: they promote the...
View ArticleThe increasing prevalence of Crohn’s disease in industrialized societies: The...
Many of the current models of experimental colitis result in a strong Th1 immune response. For example, administration of dinitrobenzene sulphonic acid or TNBS will produce a severe transmural,...
View ArticleThe increasing prevalence of Crohn’s disease in industrialized societies:...
Therefore, taking into consideration historical diseases with Th1/Th2 imbalance, the cytokine profile that exists and the epidemiological evidence showing CD as an industrialized disease, a logical...
View ArticleThe increasing prevalence of Crohn’s disease in industrialized societies:...
In contrast to a decrease in Th2 cytokines leading to the development of CD, it may be that the loss of specific antiinflammatory cytokines predisposes to runaway inflammatory episodes such as CD....
View ArticleThe increasing prevalence of Crohn’s disease in industrialized societies:...
Therefore, it could be that, consequential to the polarization of either a Th1 or Th2 response, there is an inadequate level of the anti-inflammatory cytokines (such as IL-10) needed to help subdue the...
View ArticleThe increasing prevalence of Crohn’s disease in industrialized societies:...
A decade ago, Ekbom et al demonstrated a positive correlation between in utero exposure to the measles virus and the future development of CD. While the data presented by Ekbom were convincing, and...
View ArticleThe increasing prevalence of Crohn’s disease in industrialized societies:...
Several models for the treatment and prevention of CD are currently being examined. One of these new treatment approaches involves the administration of antiinflammatory cytokines of Th2 lineage...
View ArticleThe increasing prevalence of Crohn’s disease in industrialized societies:...
Local administration of the IL-10-producing bacteria Lactococcus lactis has also proven to be beneficial in the treatment of IBD in mice . Another potential therapy could involve the use of cytokine...
View ArticleThe increasing prevalence of Crohn’s disease in industrialized societies:...
Clearly, the prospect of infecting humans with helminths is not going to be met with great enthusiasm, especially when offered as a means of preventative therapy. Therefore, additional research is...
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